PE-22-28: 10mg

PE-22-28

PE-22-28 is a synthetic heptapeptide derived from spadin, a natural peptide that acts as an antagonist of the TREK-1 potassium channel. TREK-1 has emerged as a significant target in neuroscience research due to its role in mood regulation, neuroplasticity, and neuronal excitability. PE-22-28 represents a more potent and selective TREK-1 blocker than its parent compound.

Mechanism of Action

PE-22-28 blocks TREK-1 (TWIK-related potassium channel-1), a two-pore domain potassium channel expressed widely in the central nervous system. TREK-1 normally hyperpolarizes neurons, reducing their excitability. By inhibiting this channel, PE-22-28 increases neuronal firing rates and enhances neurotransmitter release. Research has shown that TREK-1 knockout mice display resistance to depression-like behaviors, and TREK-1 antagonism has been associated with increased hippocampal neurogenesis, BDNF expression, and serotonergic transmission in preclinical models.

Key Research Applications

Published peer-reviewed studies have investigated this compound in the context of TREK-1 channel pharmacology, mood regulation pathways, hippocampal neurogenesis, BDNF expression, serotonergic neurotransmission, and neuronal excitability and plasticity. Researchers continue to explore its potential across multiple experimental models, with a growing body of literature supporting further investigation.

What You Receive

(1) Vial containing 10mg lyophilized powder. Requires reconstitution with bacteriostatic water (sold separately). Syringes not included.

Storage

Store lyophilized (freeze-dried) peptide at -20C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2-8C and use within 30 days. Protect from light and avoid repeated freeze-thaw cycles.

Quality Assurance

Every batch is independently tested by a third-party laboratory using HPLC and mass spectrometry to verify 99%+ purity. A Certificate of Analysis (COA) is included with your order. Produced in a GMP-certified, ISO-compliant facility with full batch traceability.

Note: This product is sold strictly for research, laboratory, and analytical purposes only. Not intended for human consumption. All researchers are responsible for ensuring compliance with applicable institutional, local, and federal regulations.