NAD+

NAD+ (Nicotinamide Adenine Dinucleotide)

NAD+ is a critical coenzyme found in every living cell, essential for over 500 enzymatic reactions including energy metabolism, DNA repair, and gene expression regulation. NAD+ levels decline substantially with age - by approximately 50% between ages 40 and 60 - and this decline has been identified as a central driver of metabolic dysfunction and aging in landmark research by Dr. David Sinclair at Harvard Medical School and others.

Mechanism of Action

NAD+ serves as a substrate for three critical enzyme families: sirtuins (SIRT1-7), which regulate gene expression, inflammation, and mitochondrial function; PARPs (poly-ADP-ribose polymerases), which mediate DNA repair; and CD38/CD157, which regulate immune cell signaling. As NAD+ levels decline with age, these essential repair and maintenance processes become progressively impaired. Supplementing NAD+ directly provides the substrate needed to maintain sirtuin activity, PARP-mediated DNA repair, and mitochondrial electron transport chain efficiency.

Key Research Applications

Published peer-reviewed studies have investigated this compound in the context of sirtuin activation and gene regulation, DNA repair and genomic stability, mitochondrial function and biogenesis, cellular energy metabolism, age-related NAD+ decline, neurodegeneration models, and healthspan and longevity research. Researchers continue to explore its potential across multiple experimental models, with a growing body of literature supporting further investigation.

What You Receive

(1) Vial containing lyophilized powder (available in 500mg and 1000mg). Requires reconstitution with bacteriostatic water (sold separately). Syringes not included.

Storage

Store lyophilized (freeze-dried) peptide at -20C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2-8C and use within 30 days. Protect from light and avoid repeated freeze-thaw cycles.

Quality Assurance

Every batch is independently tested by a third-party laboratory using HPLC and mass spectrometry to verify 99%+ purity. A Certificate of Analysis (COA) is included with your order. Produced in a GMP-certified, ISO-compliant facility with full batch traceability.

Note: This product is sold strictly for research, laboratory, and analytical purposes only. Not intended for human consumption. All researchers are responsible for ensuring compliance with applicable institutional, local, and federal regulations.

Note: This product is sold for research, laboratory, and analytical purposes only. Not intended for human consumption.