MOTS-C 1OMG

MOTS-c

MOTS-c (Mitochondrial-Derived Peptide) is a 16-amino acid peptide encoded by the 12S rRNA gene of mitochondrial DNA. It is the first mitochondrial-derived peptide shown to regulate nuclear gene expression, establishing a novel mitochondria-to-nucleus signaling pathway known as retrograde signaling. Its discovery has opened an entirely new dimension in metabolic and aging research.

Mechanism of Action

MOTS-c activates the AMPK pathway (AMP-activated protein kinase), the master regulator of cellular energy homeostasis. Once activated, AMPK triggers a cascade of metabolic adaptations including enhanced glucose uptake, increased fatty acid oxidation, and improved mitochondrial function. Uniquely, MOTS-c can translocate to the cell nucleus under metabolic stress, where it directly regulates nuclear gene expression related to antioxidant defense and metabolic adaptation. Research has shown that circulating MOTS-c levels decline with age, correlating with metabolic dysfunction.

Key Research Applications

Published peer-reviewed studies have investigated this compound in the context of AMPK pathway activation, mitochondrial function and biogenesis, glucose and lipid metabolism, exercise mimetic effects, aging and metabolic decline models, insulin sensitivity, and nuclear-mitochondrial communication. Researchers continue to explore its potential across multiple experimental models, with a growing body of literature supporting further investigation.

What You Receive

(1) Vial containing 10mg lyophilized powder. Requires reconstitution with bacteriostatic water (sold separately). Syringes not included.

Storage

Store lyophilized (freeze-dried) peptide at -20C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2-8C and use within 30 days. Protect from light and avoid repeated freeze-thaw cycles.

Quality Assurance

Every batch is independently tested by a third-party laboratory using HPLC and mass spectrometry to verify 99%+ purity. A Certificate of Analysis (COA) is included with your order. Produced in a GMP-certified, ISO-compliant facility with full batch traceability.

Note: This product is sold strictly for research, laboratory, and analytical purposes only. Not intended for human consumption. All researchers are responsible for ensuring compliance with applicable institutional, local, and federal regulations.

Note: This product is sold for research, laboratory, and analytical purposes only. Not intended for human consumption.