SS-31 10mg

SS-31 (Elamipretide)

SS-31, also known as Elamipretide and MTP-131, is a synthetic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that selectively targets and concentrates within the inner mitochondrial membrane. It is the first compound of its kind - a mitochondria-targeted peptide that directly stabilizes the electron transport chain and restores bioenergetic function. SS-31 has been the subject of extensive preclinical and clinical research across multiple disease models linked to mitochondrial dysfunction.

Mechanism of Action

SS-31 selectively binds to cardiolipin, a phospholipid unique to the inner mitochondrial membrane that is essential for the structural organization of electron transport chain complexes. By stabilizing cardiolipin interactions, SS-31 optimizes electron transport chain efficiency, reduces electron leak, and decreases the production of reactive oxygen species (ROS) at their primary source. This is mechanistically distinct from conventional antioxidants, which scavenge ROS after they are produced. SS-31 concentrates in mitochondria at 1000-5000x its extracellular concentration due to its Szeto-Schiller peptide structure.

Key Research Applications

Published peer-reviewed studies have investigated this compound in the context of mitochondrial electron transport chain optimization, cardiolipin stabilization, ROS reduction at the source, bioenergetic function restoration, age-related mitochondrial decline, cardiac and skeletal muscle bioenergetics, and renal mitochondrial function. Researchers continue to explore its potential across multiple experimental models, with a growing body of literature supporting further investigation.

What You Receive

(1) Vial containing 10mg lyophilized powder. Requires reconstitution with bacteriostatic water (sold separately). Syringes not included.

Storage

Store lyophilized (freeze-dried) peptide at -20C for long-term stability. After reconstitution with bacteriostatic water, refrigerate at 2-8C and use within 30 days. Protect from light and avoid repeated freeze-thaw cycles.

Quality Assurance

Every batch is independently tested by a third-party laboratory using HPLC and mass spectrometry to verify 99%+ purity. A Certificate of Analysis (COA) is included with your order. Produced in a GMP-certified, ISO-compliant facility with full batch traceability.

Note: This product is sold strictly for research, laboratory, and analytical purposes only. Not intended for human consumption. All researchers are responsible for ensuring compliance with applicable institutional, local, and federal regulations.